Accessed 29 June 2021. Jun 21, 2021. There is no screening or vetting of the report and no attempt to determine if the vaccine was responsible for the problem. So the vaccines should be perfectly safe, even in light of this new information. work will be critical to understanding the types of memory But the devil and his seed cannot go into it !!!! Jonas Salk used them to create his polio vaccine in the 1950s, and they're the bases for vaccines against other diseases including rabies and hepatitis A. Theres been a growing consensus that SARS-CoV-2 affects the vascular system, but exactly how it did so was not understood. Kelly, Jeannie. Salk researchers and collaborators show how the protein damages cells, confirming COVID-19 as a primarily vascular disease. An open space or just an open window could reduce the virus transmission. By: Express News Service Since many cardiovascular diseases are silent killers, those people may have their vascular system very damaged and only show any health problem in the future. Using her knowledge of physiology and infectious disease, Professor Janelle Ayres studies ways to help patients better tolerate infections, such as pneumonia and the acute respiratory distress syndrome (ARDS) that occurs in COVID-19 patients. Incredible this document is even published. SARS-CoV-2 Spike Protein Impairs Endothelial Function via Downregulation of ACE 2. Circulation Research. This frees the (likely many) whole and partial spike proteins inside the cell into the blood. The Salk Institute embodies Jonas Salks mission to dare to make dreams into reality. 10 June 2021. The spike protein encoded by the mRNA vaccines (Moderna and Pfizer/BioNTech) and the J&J vaccine instruct the cells in our arm (where the injection is given) to produce spike protein that is tethered to the surface of the cell. When the cell dies, the spike protein is released.https://www.nytimes.com/interactive/2020/health/moderna-covid-19-vaccine.html, Wrong. Had to look down and seen it ! Like. Newswise LA JOLLA-- (April 30, 2021) Scientists have known for a while that SARS-CoV-2's distinctive "spike" proteins help the virus infect its host by latching on to healthy cells. . Science in 5. Similarly, scientists studying other coronaviruses have long suspected that the spike protein contributed to damaging vascular endothelial cells, but this is the first time the process has been documented. Reading these comments Jonathan is wrong. "Novel coronavirus' spike protein plays additional key role in illness: Researchers show how the protein damages cells, confirming COVID-19 as a primarily vascular disease.". Even if breaks from the enzymes which tell your immune system not to get rid of the useless mrna the body will most likely just get rid of the mrna. Neither vaccine contains any real virus. See: https://pubmed.ncbi.nlm.nih.gov/33053430/ and https://pubmed.ncbi.nlm.nih.gov/33328624/, In Israel, where vaccination rates are much higher, myocarditis cases are under review for possible association with vaccination. In contrast, middle-aged adults with co-morbid conditions who are vaccinated may be more likely to experience delayed adverse events (on the whole). Mar 2020. Meanwhile, NPR not exactly a conspiracy website has also reported that the vaccines may contribute to more variants (hastening so-called immune escape). No vaccine or medical product is 100% safe, but the safety of vaccines is ensured via rigorous testing in clinical trials prior to authorization or approval, followed by continued safety monitoring once the vaccine is rolled out to the public to detect potential rare side effects. Science. 23 June 2021. Research from the lab of Professor Satchin Panda has found that the majority of our genes follow a day/night rhythm in many tissue types and brain regions. The spike protein, particularly the RBD, is therefore the main antigenic target for vaccine formulation. SARS-CoV-2 Spike Protein Impairs Endothelial Function via Downregulation of ACE2, Yuyang Lei, Jiao Zhang, Cara R Schiavon, Ming He, Lili Chen, Hui Shen, Yichi Zhang, Qian Yin, Yoshitake Cho, Leonardo Andrade, Gerald S Shadel, Mark Hepokoski, Ting Lei, Hongliang Wang, Jin Zhang, Jason X-J Yuan, Atul Malhotra, Uri Manor, Shengpeng Wang, Zu-Yi Yuan, and John Y-J Shyy, Office of Communications Anyone can submit a report of an event to VAERS, even if its not clear that a vaccine caused the problem, and all of the notifications are accepted without determining if the event was caused by a vaccine. I dont know if this should worry me more or the same (?). The spike also activates CD4 and CD8 T cells from anywhere beyond 70% of COVID-19 patients . Based on this outline, we have reviewed the structure . We thought the spike protein was a great target antigen, we never knew the spike protein itself was a toxin and was a pathogenic protein. 27 apr 2021. it unavoidably raises questions about the new vaccines that contain billions of spike proteins that could . The foundation hasno controlover our editorial decisions, and the views expressed in our articles do not necessarily reflect the views of the foundation. At the same time, clinicians can sequence the virus, providing valuable information on the spread of COVID-19 mutations and variants. Vaccination is a calculated risk and with tried and true vaccines the risks are very rare, but no vaccine is safe in that deaths and injuries occur due to allergies, negligence and medical incompetence. This means that very large amounts of circulating spike proteins are produced, generating the adverse effects that the authors identified in their study. Click link below to sign up for our monthly newsletter. The short answer is absolutely not, Bridle says in the radio show. What leads you to believe that the spike protein will remain in the cell vs. expressed into the surrounding tissue by which not only antibody response will be built up (a good thing) but also attack by NK cells (another aspect of the immune system) and thus pro-thrombotic, pro-inflammatory aftereffects? 6 replies 0 retweets 21 likes. 10 June 2021. , have subsequently identified only a few, very rare adverse events. Pharmacokinetics is the, Virus Spike Protein vs. Vaccine-Generated Spike Protein, Thats because the SARS-CoV-2 spike protein is a, . e unevidenced. That could explain why some people have strokes, and why some people have issues in other parts of the body. As its website explains, VAERS is not designed to detect if a vaccine caused an adverse event, but it can identify unusual or unexpected patterns of reporting that might indicate possible safety problems requiring a closer look.. Accessed 29 June 2021. FACT: The COVID-19 vaccine will not affect fertility. The new technology treatments give mRNA to teach your own cells to make the spike proteins. COVID, on the other hand, is known to have significant effects on many tissues and organs, he said. Of course, none of this even begins to account for how vaccines will alter our immune response, for better or for worse, to COVID-19 variants. If a burgler, theoretically, is born inside your house and cannot get out alive and is killed by the residents, there is no damage and no damage in the future at other houses. Instead, each carries molecular instructions, called messenger RNA (mRNA), that tell our bodies how to fight off the virus. The vaccines are clearly beneficial to elderly people but I would never let my children be vaxxed without long term studies. These include events that happen both in the womb as well as after birth. Watch the video. Low, Jia Ming, et al. what is the half -life or the time scale the mRNA and the proteins will be floating around until mRNA is degraded and the spike proteins are met by the immune system? But authors of two of the studies he cites told us their findings dont back Bridles statements. Scientists have known for a while that SARS-CoV-2 's distinctive "spike" proteins help the virus infect its host by latching on to healthy cells. Its internationally renowned and award-winning scientists explore the very foundations of life, seeking new understandings in neuroscience, genetics, immunology, plant biology and more. While the findings themselves arent entirely a surprise, the paper provides clear confirmation and a detailed explanation of the mechanism through which the protein damages vascular cells for the first time. over our editorial decisions, and the views expressed in our articles do not necessarily reflect the views of the foundation. RNA-targeting CRISPR-Cas technology to destroy the The development of the COVID-19 mRNA vaccines was possible, in part, because of the groundwork Holleys foundational science provided. These vaccines have been found to be effective and safe in clinical trials with tens of thousands of participants, and in real world conditions with over 325 million doses administered. It is a beautiful forest with trees so tall and wide. A post widely shared on social media claims a viral immunologist said COVID-19 vaccines' spike protein means people are being inoculated "with a toxin." Experts say there is no evidence that the . Which is totally different from the wild version. University of Guelph. Why did he or she do it ? Ogata, Alana, et al.Circulating SARS-CoV-2 Vaccine Antigen Detected in the Plasma of mRNA-1273 Vaccine Recipients. Clinical Infectious Diseases. The COVID-19 vaccine argument thus far has been one-size-fits all: COVID-19 vaccinations are harmful (antivaxxers) vs. helpful (the majority). Using a newly developed mouse model, researchers found that exposure to the SARS-CoV-2 spike protein alone was enough to induce COVID-19-like symptoms including severe inflammation in the lungs. 9. The vaccine allows the body to recognize spike proteins so it can learn to fight them, without the risk of a virus that can replicate spike proteins to the point of killing a person. An analysis of blood plasma samples from people who recovered from SARS-CoV-2 infections shows that most of the antibodies circulating in the blood -- on average, about 84% -- target areas of the viral spike protein outside the receptor binding domain (RBD, green), including the N-terminal Domain (NTD, blue) and the S2 subunit (red, yellow). Word of caution re long term safety and giving the vax to young people The PAH survival is 3 years.Im one of those skeptical regarding the vaccines, yet I took the first dose of Pfizer. If you remove the replicating capabilities of the virus, it still has a major damaging effect on the vascular cells, simply by virtue of its ability to bind to this ACE2 receptor, the S protein receptor, now famous thanks to COVID, Manor explains. Some such claims are. A new study co-led by Assistant Research Professor Uri Manor and UC San Diego shows that the proteins also play a key role in the disease itself. Where,when,and how, the virus entered the human biological systems. An explosive new study by researchers at the prestigious Salk Institute casts doubt on the current crop of gene-based vaccines that may pose a grave risk to public health. Retweet. Centers for Disease Control and Prevention. Two of the earliest vaccines approved in the US were delivered by Moderna and Pfizer-BioNTech. BNT162b2 vaccination induces SARS-CoV-2 specific antibody secretion into human milk with minimal transfer of vaccine mRNA, Viral Posts Misuse VAERS Data to Make False Claims About COVID-19 Vaccines. COVID-19 spike protein damages blood vessels The "spike" proteins that the coronavirus uses to help it break into cells inflicts other damage as well, according to a new study that shines a. The Pfizer and Moderna COVID-19 vaccines use mRNA technology to instruct a person's cells on how to create a piece of a spike protein. You retards fell asleep in biology 101 of high school and it shows. If you have access to any vaccine, please take it, they are all good to protect you and your loved ones. Institute's Dr. Kjesten Wiig, Executive Director of VAANZ. Scientists have known for a while that SARS-CoV-2's distinctive "spike" proteins help the virus infect its host by latching on to healthy cells. Your partnership allows our scientists to accelerate the pace of high-risk, high-reward discoveries that have the potential to benefit the health of all humanity-be it cancer, Alzheimers disease, climate change, infectious diseases or more. The, , called 2P, as in two proline molecules, is, No Evidence Vaccine-Generated Spike Protein Is Harmful, prepared in response to the attention brought by the interview, Bridle says the Canadian government should be called upon to immediately halt the mass vaccination program of children and adolescents. He says there is no immediate threat of severe COVID-19 in the majority of Canadian children and adolescents, and that more safety and efficacy data is needed for the use of experimental vaccines., the use of the Pfizer/BioNTech COVID-19 vaccine in children 12 to 15, following authorization of the vaccine in youth 16 years old and older in December. Professor Greg Lemke is delving into how receptors regulate the immune response and is studying ways to prevent the cytokine storms that develop in COVID-19, as the body produces such an overwhelming immune response in the lung that the collateral damage can be lethal for patients. We discuss the paper, the authors' clarification. They travel extensively through the lymph system and a large number end up in the spleen. Scientists have known for a while that SARS-CoV-2s distinctive spike proteins help the virus infect its host by latching on to healthy cells. a test to detect the presence of COVID-19 genomes in human My assumption is that it depends on the number of virus particles the person receives within a certain period.If you get in a close contact with someone who has already contracted the virus and spend hours together (like in a hospital room or a small office) theres a high chance for both to replicate and exchange the virus back and forth more and more exponentially and overloading your bodies before their immune systems respond. inflammatory proteins called cytokines, colloquially known as The vaccine has a limited number of spike proteins, and since its not part of a virus it cannot reproduce. Office of Communications. Home - Science - Research - Coronavirus Research. . Press release, Government of Canada, Health Canada. helps the virus in promoting the production of its own viral immunity. Expert groups continue to recommend use of the drug during pregnancy when necessary and in consultation with a doctor. Even if the spike protein was absorbed into the blood stream, it has no mechanism of action to cause any issues such as bleeding disorders., According to the CDCs website there is limited data available on the safety and the effects of vaccination in lactating people or breastfed babies because the clinical trials didnt include people who were breastfeeding. Other immune cells will be activated that can seek out and destroy future coronavirus-infected cells displaying the spike. So clean,white,and pure. I just listened to a simplified lecture on why the spike proteins are mostly destroyed inside the cell as some of the pro-vacciners stated. See: https://www.jpost.com/health-science/could-an-mrna-vaccine-be-dangerous-in-the-long-term-649253, If these spike proteins are expressed in endothelial cells, which are found in the vascular system, brain and other organs, the protein can presumably damage that tissue in a way that may not be readily apparent. I am reading and learning from the comments and knowledge above. shows that SARS-CoV-2's "distinctive 'spike' protein . While previously working on a vaccine for MERS, a disease caused by another coronavirus, McLellan and others, that by adding two proline molecules to the spike protein, they could lock it into its pre-fusion state, triggering a more effective immune response and preventing cell entry. To fuse its viral membrane with the host cell membrane it substantially changes its shape from an unstable pre-fusion state to a stable post-fusion state. With nRNA vaccine technology the spike protein is made inside the cellular machinery, but it goes on to be destroyed once it is made inside the cells and CAN NOT EXIT the Cell intact. So its like the spike protein is a burglar. 4 June 2021. I am not as much worried about anaphylaxis but I read that the latest discoveries and treatments for hives involve anti-coagulants regarding a thrombin factor level. COVID-19 Vaccine Research at U of G Awarded Provincial Funding. Ontario Veterinary College website. Dont the mRNA vaccines produce spike proteins? because its a way of being quickly alerted to a potential safety issue with a vaccine, which can then be followed-up by government scientists. in May, collected plasma from 13 health care workers at the Brigham and Womens Hospital in Boston who had received two doses of mRNA vaccine. Keanna Ghazvini, a Pfizer spokesperson, told us in an email that the document referred to by Bridle, which is mostly in Japanese, is a pharmacokinetics overview of the companys vaccine. Similarly, scientists studying other coronaviruses have long suspected that the spike protein contributed to damaging vascular endothelial cells, but this is the first time the process has been documented. And I understand some clots as well, including with the Pfizer vaccine.I am asking this also because I want to get vaccinated but just like the previous comment with the autoimmune condition, I have had an autoimmune condition, the hives on and off for the past 15years (I am not that young anymore though), cause unknown although stress and some chemicals make them worse. It is now known that many of the toxid effects of being infected by SARS COV 2 stem directly from the spike protein ie the spike protein itself is a pathogen. on SARS-CoV-2 antibodies in breast milk following vaccination, told us there is no evidence to support Bridles claims. Vol. Yuan, Atul Malhotra, Jin Zhang of the University of California San Diego; Lili Chen, Qian Yin, Ting Lei, Hongliang Wang and Shengpeng Wang of Xian Jiatong University Health Science Center in Xian, China. 6 Cardiology, the Affiliated Hospital of Yangzhou University (H.S.). Salk Institute researchers have told us - without any ambiguity - that the spike protein is a fundamental part of the Covid-19 disease. However, it says, based on available data COVID-19 vaccines are thought not to be a risk.. In reality, the jury is still out which is why these are approved for emergency use, not FDA approved in the usual (years long) tradition. Salk researchers collaborated with scientists at the University of California San Diego on the paper, including co-first author Jiao Zhang and co-senior author John Shyy, among others. Lonely Hearts at Risk: Lifelong Bachelors Face Dire Prognosis With Heart Failure, Galactic Explosion Reveals New Details About the Universe, New Technology Can Detect Cancer Cells Without Invasive and Expensive Surgery, Chemotherapy Chaos: Tumor Cells Response to Treatment Is Driven by Randomness, Chunky Dunk? 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